Instructor:	Sandy Lazarowitz	- email: sgl5@cornell.edu	- phone: 5-7830
TA:		- email:	- phone:

Text Books for the Course

Fields' "Fundamental Virology" Third Edition (required text)
Davis et al. "Microbiology" (on reserve in Biology and Med. School libraries)

HINT: If you need a hard copy of this page, just click on the Print button above.
There is also a Calendar List for each day of the course with links to the topics covered.

Jan 22-24 Definitions, Classification, and Structure

• Harrison, Skehel & Wiley (in Fields) Ch 3: "Principles of Virus Structure" pp 59-80 (up through Adenovirus structure)
• Chapter 44 (in Davis) "The Nature of Viruses" pp 769-783 (through "Other Virion Components)

Jan 27-Feb 5 Multiplication, Genetics, Cultivation and Assays

• Knipe (in Fields) Ch. 8 "Virus-Host Cell Interactions"
  
• Simons et al. (1982) "How an Animal Virus gets into and out of its host cell". Sci. Am. 246:58-66
  
• Coen & Ramig (in Fields) Ch. 4: "Animal Virus Genetics"
  
  pp 101-110 (through "Marker Transfer Linked to a Viral Gene")
  pp 112-115 (from "Types of Mutations and..." through "Interference")
  pp 117-124 (from "Mapping Mutations and Genes" through "Complementation").
  

  Chapter 44 (in Davis) "The Nature of Viruses" pp 785-789

Feb 7-Feb 14 Pathogenesis and Persistence

• Tyler and Fields (in Fields) Ch. 6: "Pathogenesis of Viral Infections"
  pp 161-173 (through "Neural Spread)
  pp 174-179 (from "Tropism" through "Site of Entry and Pathway of Spread")
  pp 184- 191 (from "Selected Mechanisms of Viral..." through end of chapter).

  Ahmed, Morrison and Knipe (in Fields) Ch. 7 "Persistence of Viruses" pp 207-222 (through "Epstein-Barr Virus")

  Garcia-Blanco and Cullen BR (1991) "Molecular basis of latency in pathogenic human viruses." Science 254:815-20

  Johnston et al (1995) "Measles virus replication in neural cells". Trends in Microbiol. 3:

Feb 17 Immunology (A brief overview)

• Whitton and Oldstone (in Fields) Ch. 10: "Immune Response to Viruses"
  pp 311-319 (through ""Biological Importance of the Difference Between...)
  pp 325-337 (from "Immunoglobin Genes" through end of chapter).

  Zinkernagel (1996) "Immunology taught by viruses". Science 271: 173-178.

Feb 19-24 Interfering with Viral Infections

• Vilcek and Sen (in Fields) Ch. 11: "Interferons and Other Cytokines"

Feb 26-Feb 28 Picornaviruses

• Ruekert (in Fields) Ch. 16:"Picornaviridae: The Viruses and Their Replication"

Mar 3 Togaviruses

• Schlesinger and Schlesinger (in Fields) Ch. 17: "Togaviridae: The Viruses and Their Replication"

Mar 5 EXAM I

Mar 7 Togaviruses, Cont'd

Mar 10-12 Rhabdoviruses

• Wagner and Rose(in Fields) Ch. 19: "Rhabdoviridae: The Viruses and Their Replication"
• Schneider (1995) "Rabies virus vaccines". Dev Biol Stand 84:49-54

Mar 14 Paramyxoviruses

• Lamb and Kolakovsky (in Fields) Ch. 20" "Paramyxoviridae: The Viruses and Their Replication"
• Murray et al (1995) "A morbillivirus that caused fatal disease in horses and humans" Science 268:94-97
• Nowak (1995) Cause of fatal outbreak in horses and humans traced [news; comment] Science 268:32

Mar 17-21 Orthomyxoviruses

• Lamb (in Fields) Ch. 21: Orthomyxoviridae: The Viruses and Their Replication"
• Wharton et al. (1989) "Structure, function and antigenicity of the hemagglutinin of influenza virus" in The Influenza Viruses, pp 153-173

Mar 24-28 Spring Break, NO CLASS

Mar 31 -Apr 2 Bunyaviruses

• Schmaljohn (in Fields) Ch. 22: "Bunyaviridae: The Viruses and Their Replication"
• Morse (1994) "Hantaviruses and the hantavirus outbreak in the United States. A case study in disease emergence. Ann N Y Acad Sci 740:199-207

Apr 4 EXAM II

Apr 7-14 Retroviruses

• Coffin (in Fields) Ch. 26: "Retroviridae: The Viruses and Their Replication"
• Nevins and Vogt (in Fields) Ch. 9: "Cell Transformation by Viruses"
• Cavenee and White (1995) "The genetic basis of cancer". Sci Am 272 (Mar):72-79

• HIV and AIDS:

• Luciw (in Fields) Ch. 27: "Human Immunodeficiency Viruses and their Replication"
• Van de Perre (1995) "The epidemiology of HIV infection and AIDS in Africa". Trends Microbiol 3:217-22
• Johnston and Hoth (1993) "Present status and future prospects for HIV therapies". Science 260:1286-1293
• Weiss (1993) "How does HIV cause AIDS?" Science 260:1273-1279
• SPECIAL NEWS REPORT (1994): "The Duesberg Phenomenon". Science 266:1642-1649

Apr 16-21 Papovaviruses

• Cole (in Fields) Ch. 28: "Polyomavirinae: The Viruses and Their Replication"
• Howley (in Fields) Ch. 29: "Papillomavirnae: The Viruses and Their Replication"
• McKnight and Tjian (1986) "Transcriptional selectivity of viral genes in mammalian cells". Cell 46:795-805.
• Struhl (1989) "Helix-turn-helix, zinc-finger, and leucine-zipper motifs for eukaryotic transcriptional regulatory proteins". TIBS 14:137-140

Apr 23-25 Adenoviruses

• Shenk (in Fields) Ch. 30: "Adenoviridae: The Viruses and Their Replication"
• Dorner (1995) "An overview of vaccine vectors". Dev Biol Stand 84:23-32

Apr 28-30 Herpesviruses

• Roizman and Sears (in Fields) Ch. 32: "Herpes simplex viruses and their Replication"
• Stanberry (1995) "Herpes simplex virus vaccines as immunotherapeutic agents". Trends in Microbiol. 3: 244-247.
• Keiff (in Fields) Ch. 33: "Epstein-Barr Virus and its Replication"

May 2-5 Hepadnaviruses

• Ganem (in Fields) Ch. 35: "Hepadnaviridae: The Viruses and Their Replication"
• Taylor (in Fields) Ch. 36: "Hepatitis Delta Virus and Its Replication"
• Steffen (1993) "Hepatitis A and hepatitis B: risks compared with other vaccine preventable diseases and immunization recommendations". Vaccine 11:518-520

May 7 Review Day, Fun Topics

May 10 FINAL, 8-11 AM, Gregory Hall Room 319

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